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CYDECTIN TriclaMox 1 mg/ml + 50 mg/ml, Oral Solution for Sheep
- Moxidectin is a second generation of Macrocyclic lactone (ML) of the milbemycine group combined with triclabendazole. Both are molecules with a very high potency
- Only ML with proven persistency on major nematodes
- Triclabendazole is active against adults and all immature stages of Fasciola hepatica
- Moxidectin is a molecule that delays development of anthelmintic resistance and is active against some benzimidazole- and avermectine-resistant strains of nematodes
- Convenient in its use to treat mixed infestations (nematode and trematode)
- Short withdrawal time
Description
Cydectin TriclaMox Oral Solution for sheep is a clear yellow to brown liquid oral solution containing per ml:
| Active substances: | |
|---|---|
| Moxidectin | 1.0 mg |
| Triclabendazole | 50.0 mg |
| Excipients: | |
| Benzyl alcohol | 40 mg |
| Butylhdroxytoluene | 1,0 mg |
INDICATIONS
For the treatment of mixed nematode and fluke infections in sheep, caused by moxidectin and triclabendazole sensitive strains of:
| Parasite | Adult stage | L4 | Inhibited stages |
| Gastro-intestinal nematodes: | |||
| Haemonchus contortus | ● | ● | ● |
| Teladorsagia circumcincta | ● | ● | ● |
| Ostertagia trifurcata | ● | ● | |
| Trichostrongylus axei | ● | ● | ● |
| Trichostrongylus colubriformis | ● | ● | |
| Trichostrongylus vitrinus | ● | ● | |
| Nematodirus battus | ● | ● | |
| Nematodirus spathiger | ● | ● | |
| Nematodirus filicolis | ● | ||
| Strongyloides papillosus | ● | ||
| Cooperia curticei | ● | ||
| Cooperia oncophora | ● | ● | |
| Oesophagostomum columbianum | ● | ● | |
| Oesophagostomum venulosum | ● | ||
| Chabertia ovina | ● | ● | |
| Trichuris ovis | ● | ||
| Respiratory tract nematode: | |||
| Dictyocaulus filaria | ● | ||
| Liver fluke: | Adult stage | Early Immature stages | Late Immature stages |
| Fasciola hepatica | ● | ● | ● |
The product has a persistent efficacy and protects sheep against infection or re-infection with the following parasites for the period indicated:
| Species | Protection period (days) |
|---|---|
| Teladorsagia circumcincta | 35 |
| Haemonchus contortus | 35 |
Clinical trials, after experimental and natural infection, have shown that the product is effective against certain benzimidazole resistant strains of:
- Haemonchus contortus
- Teladorsagia circumcincta
- Trichostrongylus colubriformis
- Cooperia curticei
CONTRAINDICATIONS
Do not use in cases of hypersensitivity to the active substance(s) or to any of the excipients.
ADVERSE REACTIONS
None known.
TARGET SPECIES
Sheep
DOSAGE, ROUTE AND METHOD OF ADMINISTRATION
Should be given as a single oral drench of 1 ml/5 kg bodyweight, equivalent to 0.2
mg moxidectin/kg bodyweight and 10 mg triclabendazole/kg bodyweight, using any
standard drenching equipment.
To ensure a correct dosage, body weight should be determined as accurately as
possible; accuracy of the dosing device should be checked. If animals are to be
treated collectively rather than individually, they should be grouped according
to their body weight and dosed accordingly, in order to avoid under- or overdosing.
Signs of overdoses have not been seen at 3 and 5 times the recommended dose.
However, if they do occur they should be consistent with the mode of action of
moxidectin and/or triclabendazole and would be manifested as transient salivation,
depression, drowsiness, ataxia and reduced food intake 8 to 12 hours post-treatment.
Treatment is not generally necessary and recovery is generally complete within 1
to 5 days. There is no specific antidote.
WITHDRAWAL PERIOD
Meat and offal: 31 days.
Milk: not permitted for use in sheep producing milk intended for human consumption.
Not permitted for use in pregnant dairy ewes within 2 months prior to parturition.
SHELF LIFE
Shelf life of the veterinary medicinal product as packaged for sale: 18 months
Shelf-life after first opening the container: 28 days.
SPECIAL STORAGE PRECAUTIONS
Do not store above 25°C.
Protect from light.
Do not freeze.
SPECIAL WARNINGS
- Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.>/li>
- Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any).
- Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
- Resistance to macrocyclic lactones has been reported in Teladorsagia in sheep in a number of countries. In 2008, throughout Europe, moxidectin resistance is very rare; it has been reported in a single case involving a levamisole-, benzimidazole and ivermectin-resistant strain of Teladorsagia circumcincta. Resistance to triclabendazole has been reported in Fasciola hepatica in sheep in some European countries. Therefore the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of parasites, local history of treatments and recommendations on how to use the product under sustainable conditions to limit further selection for resistance to antiparasitic compounds. These precautions are especially important when moxidectin is being used to control resistant strains.
- This product should not be used for the treatment of single infections.
- Avoid direct contact with skin and eyes.
- Wash hands after use.
- Do not smoke, drink or eat when using this product.
- Wear impermeable rubber gloves during use.
Special precautions for use in animals
The product should not enter water courses as this may be dangerous for fish and other aquatic organisms.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
OTHER INFORMATION
ATCvet Code QP54AB52, moxidectin combination
Nature and composition of immediate packaging and presentations
The product is packaged in 1L, 2.5L and 5L polyethylene containers with polypropylene screw-cap.
Not all pack sizes may be marketed.
