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DUPHAPEN + STREP Procaine Penicillin 200 mg/ml & Dihydrostreptomycin Sulphate 250 mg/ml Suspension for Injection for Cattle, Sheep, Pigs, and Horses
- DUPHAPEN STREP contains Penicillin G, that is a beta-lactamic antibiotic that prevent the bacterial cell wall of susceptible Gram-positive bacteria from forming and also contains dihydrostreptomycin, an aminoglycoside antibiotic active against gramnegative aerobes. Aminoglycosides exert synergistic action in combination with betalactamic antibiotics.
- After injection of Duphapen Strep, the procaine penicillin and dihydrostreptomycin are rapidly absorbed from the site of injection. It is used for the treatment of systemic infections in cattle, horses, sheep and pigs caused by or associated with organisms sensitive to penicillin and/or streptomycin.
- Duphapen Strep is marketed in 50ml and 100ml multidose glass vials.
Description
Duphapen + Strep is a white to off white suspension for injection Each ml of product contains:
| Active ingredient: | |
|---|---|
| Procaine Benzylpenicillin (procaine penicillin) | 200mg |
| Dihydrostreptomycin Sulphate | 250mg |
| Excipients | |
| Nipasept sodium | 1.5 mg |
INDICATIONS
For the treatment of systemic infections in cattle, horses, sheep and pigs caused by or associated with organisms sensitive to penicillin and/or streptomycin including:
- Corynebacterium pyogenes
- Erysipelothrix rhusiopathiae
- Klebsiella pneumoniae
- Listeria spp
- Mannheimia haemolytica
- Pasteurella multocida
- Staphylococcus spp (non-penicillinase producing)
- Streptococcus spp (non-penicillinase producing)
- Salmonella spp
CONTRAINDICATIONS
Do not use in known cases of hypersensitivity to penicillins.
Do not administer with other antibiotics such as tetracyclines or with other aminoglycodies.
ADVERSE REACTIONS
Occasionally in suckling and fattening pigs, administration may cause a transient pyrexia, vomiting, shivering, listlessness and inco-ordination. A mild transient local reaction may occur at the site of injection in horses. Additionally, in pregnant sows and gilts, a vulval discharge which could be associated with abortion has been reported.
TARGET SPECIES
Cattle, sheep, pigs, horses
DOSAGE, ROUTE AND METHOD OF ADMINISTRATION
Shake the vial before use.
Administer by deep intramuscular injection.
Recommended dosage rate is 8mg/kg bodyweight procaine penicillin with 10 mg/kg
bodyweight dihydrostreptomycin sulphate equivalent to 1ml per 25kg bodyweight. Treatment
should be given once daily for up to three consecutive days. The maximum dose volume
administered at one site should not exceed 15ml for horses, 6ml for cattle, 3 ml for sheep and
1.5 ml for pigs.
WITHDRAWAL PERIOD
Animals must not be slaughtered for human consumption during treatment.
Milk must not be taken during treatment.
National label conditions must be observed by country.
SHELF LIFE
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Following withdrawal of the first dose, use the product within 28 days.
SPECIAL STORAGE PRECAUTIONS
Do not store above 25 °C.
Keep the container in the outer carton to protect from light.
SPECIAL WARNINGS
Special precautions for use in animals
An appropriately graduated syringe must be used to allow accurate administration
of the required dose volume. This is particularly important when injecting small volumes.
Use with care in animals known to have kidney disease or defective renal function.
Do not exceed the recommended dosage or duration of treatment.
Not for intravenous or intrathecal administration.
Aminoglycosides have a narrower margin of safety than beta-lactam antibiotics.
Duphapen + Strep can be safely administered to pregnant and lactating animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillins and Cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to Penicillins may lead to cross
reactions to Cephalosporins and vice versa. Allergic reaction to these substances may
occasionally be serious.
- Do not handle this product if you know you are sensitised or if you have been advised not to work with such preparations.
- Handle this product with great care to avoid exposure, taking all recommended precautions.
- If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
OTHER INFORMATION
ATCvet Code QJ01CR
Nature and composition of immediate packaging
Nature of the primary container:
Clear type II multidose glass vials of 50 ml and 100 ml.
National label conditions must be observed by country.
