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Poulvac Marek CVI, Frozen virus-infected cell suspension, after thawing to be diluted in Poulvac Marek Diluent for Chickens.
- Marek's disease remains one of the most important diseases in the world in terms of economical losses.
- Poulvac Marek contains the original CVI strain provided by Dr. Rispens
- CVI monovalent is used in situations when field pressure does not require the bivalent product CVI+HVT
Description
| Active Ingredients: | Per 0.2 ml dose | |
|---|---|---|
| Live Marek's disease virus, strain CVI 988, cell associated | >103.0 TCID50 | |
| Poulvac Marek Diluent: | Dose volume | |
| 0.2 ml | 0.5 ml | |
| Sucrose | 10.25 mg | 25.62 mg |
| Potassium dihydrogen phosphate | 0.10 mg | 0.26 mg |
| Potassium monohydrogen phosphate | 0.25 mg | 0.63 mg |
| Peptone (NZ amine) | 3.00 mg | 7.50 mg |
| Amaranth* (E123) | 4.00 mg | 10.00 mg |
| Aqua ad injectabilia ad | 0.20 mg | 0.50 mg |
| *In case Phenol Red is used | 2.00 μg | 5.00 μg |
INDICATIONS
For the active immunisation of chickens to reduce mortality and lesions caused by Marek's
Disease.
The onset of immunity is from 3 days of vaccination and the duration of immunity is not
known but has been shown by challenge to be at least 4 weeks. Vaccine virus and antibodies
to Marek's disease virus have been shown to persist in vaccinated chickens for up to 2 years.
CONTRAINDICATIONS
Do not vaccinate unhealthy chickens.
ADVERSE REACTIONS
No local or systemic reactions have been observed following the administration of the vaccine during safety studies. However, and in common with other immunological products, it is expected that local or systemic reactions may occur in a very small proportion of vaccinated birds.
TARGET SPECIES
Chickens from one day of age.
DOSAGE, ROUTE AND METHOD OF ADMINISTRATION
One 0.2 ml dose per chicken.
The vaccine is to be administered by intramuscular injection in the thigh muscle or by
subcutaneous injection in the neck.
Dilution of vaccine: Reconstitute each 1,000 doses with 200 ml of diluent. 2,000 dose
ampoules should be reconstituted in 400 ml of diluent. Dilution should be done under sterile
conditions with diluent at room temperature. An ampoule may occasionally explode after it
has been taken out of liquid nitrogen so goggles should be worn. Take the ampoule of vaccine
out of the container of liquid nitrogen into a bowl containing clean tepid water (temperature
27°C (80°F) and not higher than 37°C (98°F)). Thaw the vaccine concentrate by carefully
turning the ampoule, then remove from the water and dry the ampoule. The thawed vaccine
concentrate must be used immediately and cannot be refrozen.
All equipment used for vaccination should be sterile and contain no traces of detergents or
disinfectants.
Break the ampoule and withdraw the total contents carefully into a 10 ml sterile disposable
syringe, using an 18G x 1.5 inch (1.2 x 40 mm) or larger gauge needle. Slowly withdraw
about 8 ml of diluent into the syringe. Turn the syringe 5-10 times to mix the contents well.
Slowly transfer a small volume of the mixture into the empty vaccine ampoule in order to
remove the last remnants of the vaccine and withdraw this small amount back into the
syringe, and carefully transfer the entire contents of the syringe into the diluent bottle. Rotate
the bottle about 10 times to mix the contents well. The bottle of diluent should be kept closed
throughout the procedure.
The vaccine is now ready for use and should be used within 2 hours of reconstitution.
Administration: Poulvac Marek CVI may be administered either manually, preferably by
using a multi-dose syringe dose and fitted with a 23G x 1 inch (0.60 x 25 mm) needle, or by a
vaccination machine.
Administer the vaccine intramuscularly into the thigh muscle or subcutaneously in the neck.
NB During the vaccination procedure, rotate the bottle of reconstituted vaccine solution every
5 minutes to prevent the cells from sedimenting.
WITHDRAWAL PERIOD
Zero days
SHELF LIFE
Shelf-life of the veterinary medicinal product as packaged for sale:
| Poulvac Marek CVI: | 30 months |
| Poulvac Marek Diluent: | 24 months |
SPECIAL STORAGE PRECAUTIONS
The vaccine is to be stored at -196oC in a container with liquid nitrogen. Store the diluent at room temperature or at +2oC to +8oC in the dark. Avoid exposure to heat and/or direct sunlight. Once thawed, the vaccine cannot be refrozen.
SPECIAL WARNINGS
Vaccine virus spreads from bird to bird. In a study in highly susceptible Rhode Island Red
birds, vaccine virus was shown to increase in virulence after ten passages.
Maternally derived antibody (MDA) can interfere with the development of active immunity.
Where it is likely that recent field infection or vaccination of the parent flock has stimulated a
high antibody titre and consequently a high level of MDA, the timing of the vaccination
programme should be planned accordingly.
Special precautions for use in animals
- Avoid stress in chickens before and after vaccination.
- Avoid injection into or near joints and tendons.
- To avoid all possible risks of working with liquid nitrogen and/or explosion of glass ampoules, the following precautions must be taken.
- Use of gloves.
- Use of facial protection or safety goggles.
- Use of skin-covering clothing.
If liquid nitrogen is spilt and comes into contact with skin causing frost bite injuries immediately:
Warm affected area by immersion in water at 29 + 1oC or by the use of body heat. Considerable pain will be experienced during warming but this is normal. Do not rub the affected area. Seek medical advice if full function and feeling are not rapidly restored. After handling vaccine, operators should wash and disinfect their hands with an approved disinfectant.
No information is available on the compatibility of this vaccine when used at one day of age with any other except Poulvac IBH120, Poulvac NDW, Poulvac TRT and MD Vac. Therefore the safety and efficacy of this product when used with any other than those named above (either when used on the same day or at different times) has not been demonstrated.
Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant approved for use by the competent authorities.
OTHER INFORMATION
ATCvet code: QI01AD03
Nature: glass ampoule
Contents: 2 ml (1000 or 2000 dose)
Poulvac Marek Diluent
Glass bottles
Nature: Type II hydrolytic glass bottles (Ph.Eur.) with rubber stoppers (Ph.Eur.) and
aluminium overseal
Contents: 200 ml, 400 ml or 500 ml
Collapsible plastic bag
| Nature: Pouch body: | Draka 3250, 3256 or NM80 |
| Filling tube: | Draka 3260 |
| Sep port: | Draka 3286 |
| Needle guide: | Draka 3244 |
| Stopper: | Burnet stopper |
| Additive port: | Draka 3286 |
| Contents: | 200 ml, 400 ml, 500 ml or 1 litre |
